Water → 4-Bromo-1-(2-ethoxyethoxy)-2-fluorobenzene

HRID 1978621노트

반응식

HRID 1978621 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([F:9])[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:17][CH2:18][O:19][CH2:20][CH3:21].O>CN(C=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:17][CH2:18][O:19][CH2:20][CH3:21])=[C:4]([F:9])[CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 611412-Bromoethyl ethyl ether2회HCID 27249814-Bromo-2-fluorophenol

생성물 1

HCID 219959004-Bromo-1-(2-ethoxyethoxy)-2-fluorobenzene

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a mixture of 4-bromo-2-fluorophenol (10.07 g) and potassium carbonate (9.5 g) in DMF (100 ml) was added at room temperature 2-bromoethylethyl ether (6.0 ml), and the mixture was stirred for 18 hours. To the mixture was added 2-bromoethylethyl ether (1.2 ml), and the mixture was stirred at 55° C. for 5 hours. To the mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water (thrice) and saturated brine (once), and dried with magnesium sulfate. The solvent was evaporated under reduced pressure to give pale yellow oil of 4-bromo-1-(2-ethoxyethoxy)-2-fluorobenzene (13.79 g).

후처리

  1. stirringthe mixture was stirred at 55° C. for 5 hours
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with water (thrice) and saturated brine (once), and
  4. dry with materialdried with magnesium sulfate
  5. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-2097295c9fa2417a86795caf6889427d
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06235771B1

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