Water → 5-Methoxybenzofuran

HRID 1978765노트

반응식

HRID 1978765 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH2:10][CH:11](OC)OC)=[CH:5][CH:4]=1.O>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:9][CH:10]=[CH:11][C:7]=2[CH:8]=1

참가 물질

4

반응물 2

HCID 962WaterHCID 110244p-(2,2-Dimethoxyethoxy)anisole

생성물 1

HCID 259435-Methoxybenzofuran수율 24.5%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
100 °C

실험 절차

To a suspension of polyphosphoric acid (38.3 g) in toluene (400 ml) was added 4-methoxy-(2,2-dimethoxy)ethoxybenzene (38.0 g), and the mixture was stirred at 100° C. overnight and cooled. To the mixture was added water, and the mixture was separated. The organic layer was washed with 1N sodium hydroxide solution and then washed with saturated brine, and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated, and the residue was purified with silica gel column chromatography to give brown oil of 5-methoxybenzofuran (6.5 g).

후처리

  1. temperaturecooled
  2. customthe mixture was separated
  3. washThe organic layer was washed with 1N sodium hydroxide solution
  4. washwashed with saturated brine
  5. dry with materialdried with magnesium sulfate
  6. customUnder reduced pressure, the solvent was evaporated
  7. customthe residue was purified with silica gel column chromatography

출처 및 근거

ORD 기록
ord-e1ba364eb10c41cda21078f2b7c2c28c
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06235771B1

반응 노트

불러오는 중…