1-Chloro-3-(triphenyl phosphoranylidene)propan-2-one → 3-[4-Chloro-3-(4-chloro-3-oxobut-1-enyl)-phenyl]-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine
반응식
[Cl:1][CH2:2][C:3]([CH:5]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:4].[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([N:32]2[C:37](=[O:38])[CH:36]=[C:35]([C:39]([F:42])([F:41])[F:40])[N:34]([CH3:43])[C:33]2=[O:44])=[CH:28][C:27]=1[CH:45]=O>CO>[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([N:32]2[C:37](=[O:38])[CH:36]=[C:35]([C:39]([F:41])([F:42])[F:40])[N:34]([CH3:43])[C:33]2=[O:44])=[CH:28][C:27]=1[CH:45]=[CH:5][C:3](=[O:4])[CH2:2][Cl:1]참가 물질
4
반응물 2
생성물 1
시약·촉매·용매 1
실험 절차
4.6 g of chloroacetylmethylenetriphenylphosphorane were added to a solution of 3.3 g of 3-[4-chloro-3-formylphenyl]-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine in 100 ml of methanol, and stirring was carried out for 10 hours at room temperature. The precipitate which had separated out was isolated, washed with petroleum ether and dried.