Trifluoroacetic acid → 3-(Hydroxycarbonylmethyl)-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole

HRID 1978983노트

반응식

HRID 1978983 반응식
C([O:5][C:6]([CH2:8][C:9]1[N:13]=[C:12]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][C:19]=2[C:20]([F:23])([F:22])[F:21])[O:11][N:10]=1)=[O:7])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[OH:7][C:6]([CH2:8][C:9]1[N:13]=[C:12]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][C:19]=2[C:20]([F:22])([F:23])[F:21])[O:11][N:10]=1)=[O:5]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 227440793-(Tert-butoxycarbonylmethyl)-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole

생성물 1

HCID 227440893-(Hydroxycarbonylmethyl)-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole수율 78.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

12.4 g of 3-(tert-butoxycarbonylmethyl)-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole are dissolved in 110 ml of dichloromethane and admixed with 57 ml of trifluoroacetic acid. The reaction mixture is stirred at room temperature for 1.5 hours and subsequently concentrated under reduced pressure. The residue is repeatedly taken up in dichloromethane and reconcentrated to remove any remaining trifluoroacetic acid. The mixture is finally triturated with diethyl ether, giving 8.1 g of the product as a white solid.

후처리

  1. concentrationsubsequently concentrated under reduced pressure
  2. customto remove any remaining trifluoroacetic acid
  3. customThe mixture is finally triturated with diethyl ether

출처 및 근거

ORD 기록
ord-24764e5453784298aef0f41cd9151f51
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06239160B1

반응 노트

불러오는 중…