HCID 86756878, 화합물 → (E)-2'-[(1-amino-1-cyclopentyl)carbonyl]-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2'-isobutyl-4-methylvalerohydrazide

HRID 1979192노트

반응식

HRID 1979192 반응식
C1C2C(COC([NH:18][C:19]3([C:24]([N:26]([CH2:55][CH:56]([CH3:58])[CH3:57])[NH:27][C:28](=[O:54])[C@@H:29]([C@@H:34]([C:44](=[O:53])[NH:45][O:46][CH:47]4[CH2:52][CH2:51][CH2:50][CH2:49][O:48]4)[CH2:35]/[CH:36]=[CH:37]/[C:38]4[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=4)[CH2:30][CH:31]([CH3:33])[CH3:32])=[O:25])[CH2:23][CH2:22][CH2:21][CH2:20]3)=O)C3C(=CC=CC=3)C=2C=CC=1>ClCCl.N1CCCCC1>[NH2:18][C:19]1([C:24]([N:26]([CH2:55][CH:56]([CH3:58])[CH3:57])[NH:27][C:28](=[O:54])[C@@H:29]([C@@H:34]([C:44](=[O:53])[NH:45][O:46][CH:47]2[CH2:52][CH2:51][CH2:50][CH2:49][O:48]2)[CH2:35]/[CH:36]=[CH:37]/[C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[CH2:30][CH:31]([CH3:33])[CH3:32])=[O:25])[CH2:20][CH2:21][CH2:22][CH2:23]1

참가 물질

4

반응물 1

HCID 86756878HCID 86756878, 화합물

생성물 1

HCID 86756877(E)-2'-[(1-amino-1-cyclopentyl)carbonyl]-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2'-isobutyl-4-methylvalerohydrazide수율 72.5%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8082Piperidine용매

실험 절차

A solution of 0.69 g of (E)-2′-[(1-(9-fluorenylmethyloxycarbonylamino)-1-cyclopentyl)carbonyl]-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-4-methylvalerohydrazide in a mixture of 6.4 ml of dichloromethane and 1.6 ml of piperidine was stirred at room temperature for 1 hour. The solution was evaporated and the residue was treated with diethyl ether. The ethereal solution was filtered and evaporated. Chromatography on silica gel using methanol/dichloromethane (1:33) for the elution followed by evaporation gave 0.36 g of (E)-2′-[(1-amino-1-cyclopentyl)carbonyl]-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-4-methylvalerohydrazide in the form of a white foam.

후처리

  1. customThe solution was evaporated
  2. additionthe residue was treated with diethyl ether
  3. filtrationThe ethereal solution was filtered
  4. customevaporated
  5. washfor the elution
  6. customfollowed by evaporation

출처 및 근거

ORD 기록
ord-5d3d4b4e424a4106b0839f50160507b2
출처 데이터셋
uspto-grants-2001_05
특허 번호
US06239151B1

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