Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Cyclopropyl-1-fluoro-4-iodobenzene → 3-Cyclopropyl-N-[[4-(1,1-dimethylethyl)phenyl]methyl]-4-fluorobenzeneethanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Cyclopropyl-1-fluoro-4-iodobenzene | HCID 68564110 | — |
| 반응물 | 3-(4-Tert-butylbenzyl)-[1,2,3]oxathiazolidine 2,2-dioxide | HCID 86613991 | — |
| 생성물 | 3-Cyclopropyl-N-[[4-(1,1-dimethylethyl)phenyl]methyl]-4-fluorobenzeneethanamine | HCID 68561157 | 28.3% |
반응 단계
The title compound was synthesized in analogy to example S6-C using 2-cyclopropyl-1-fluoro-4-iodobenzene (100 mg, 0.38 mmol) and 3-(4-tert-butylbenzyl)-[1,2,3]oxathiazolidine 2,2-dioxide (103 mg, 0.38 mmol). The residue was purified by flash column chromatography to give the desired product (35 mg, 28%) as a colorless oil. MS (ISP) 326.3 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745477B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-ff9c23d8d5c04f3a879a65b9a32f99fa |
| 출처 메모 | uspto-grants-2010_06 |