Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Fluorophenethylamine → N-[2-(4-fluoro-phenyl)-ethyl]-4-pentafluoroethyl-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Fluorophenethylamine | HCID 4653 | — |
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| 반응물 | 4-(1,1,2,2,2-Pentafluoroethyl)benzoic acid | HCID 23067883 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-[2-(4-fluoro-phenyl)-ethyl]-4-pentafluoroethyl-benzamide | HCID 86613992 | 99.3% |
반응 단계
A solution of 4-pentafluoroethyl-benzoic acid (500 mg, 2.08 mmol), 2-(4-fluorophenyl)ethylamine (319 mg, 2.29 mmol), 4-methylmorpholine (632 mg, 6.24 mmol), and HBTU (1.19 g, 3.12 mmol) in DMF (38 mL) was stirred at RT for 16 h, then the reaction mixture was partitioned between water and ethyl acetate. The organic layer was washed with brine, dried (MgSO4), and evaporated. Chromatography (SiO2, heptane-ethyl acetate gradient) afforded the title compound (746 mg, 99%). White solid, MS (ISP) 362.2 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745477B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-43582dbf12b64768b36d16026bb44d98 |
| 출처 메모 | uspto-grants-2010_06 |