Carbonyl fluoride → 4-Chloro-2-(trifluoromethyl)phenyl carbamic fluoride

HRID 1979628

반응식

HRID 1979628 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[O:10])=[C:4]([C:11]([F:14])([F:13])[F:12])[CH:3]=1.F.C(F)([F:18])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([F:18])=[O:10])=[C:4]([C:11]([F:12])([F:13])[F:14])[CH:3]=1

참가 물질

4

반응물 3

HCID 9623Carbonyl fluorideHCID 14917Hydrofluoric Acid2회HCID 27332644-Chloro-2-(trifluoromethyl)phenyl isocyanate

생성물 1

HCID 204396074-Chloro-2-(trifluoromethyl)phenyl carbamic fluoride

반응 조건

온도
24 °C

실험 절차

4-Chloro-2-(trifluoromethyl)phenyl carbamic fluoride was prepared in situ by the reaction of 221 parts of 4-chloro-2-(trifluoromethyl)-isocyanatobenzene and 380 parts of hydrogen fluoride added over a period of about 15 minutes at about 4° C. The reaction mixture was then sealed in a polytetrafluoroethylene reactor, heated to about 24° C. and maintained at about that temperature, with agitation, for about 96 hours. The reactor was then opened to atmospheric pressure and most of the hydrogen fluoride and carbonyl fluoride gases removed. Analysis of the remaining organic product by gas chromatographic techniques, using n-pentadecane as an internal standard, indicated as yield of 55 parts of 4-chloro-2-(trifluoromethyl)benzenamine.

후처리

  1. additionadded over a period of about 15 minutes at about 4° C
  2. customThe reaction mixture was then sealed in a polytetrafluoroethylene reactor
  3. temperaturemaintained at about that temperature, with agitation, for about 96 hours
  4. customremoved

출처 및 근거

ORD 기록
ord-3992da07c5554303858bc646bce42752
출처 데이터셋
uspto-grants-1984_11
특허 번호
US04481370

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