Carbonyl fluoride → 4-Chloro-3-(trifluoromethyl)phenyl carbamic fluoride

HRID 1979629

반응식

HRID 1979629 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[O:10])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].F.C(F)([F:18])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([F:18])=[O:10])=[CH:4][C:3]=1[C:11]([F:12])([F:13])[F:14]

참가 물질

4

반응물 3

HCID 9623Carbonyl fluorideHCID 14917Hydrofluoric Acid2회HCID 27332651-Chloro-4-isocyanato-2-(trifluoromethyl) benzene

생성물 1

HCID 204396094-Chloro-3-(trifluoromethyl)phenyl carbamic fluoride

반응 조건

온도
24 °C

실험 절차

4-Chloro-3-(trifluoromethyl)phenyl carbamic fluoride was prepared in situ by the reaction of 221 parts of 4-chloro-3-(trifluoromethyl)isocyanatobenzene and 450 parts of hydrogen fluoride added over a period of 15-20 minutes at about 4° C. The reaction mixture was then sealed in a polytetrafluoroethylene reactor, heated to about 24° C. and maintained thereat, with agitation, for about 96 hours. The reactor was then opened to atmospheric pressure and most of the hydrogen fluoride and carbonyl fluoride gases removed. Analysis of the remaining organic product by gas chromatographic techniques, using n-heptadecane as an internal standard indicated a yield of 77 parts of 4-chloro-3-(trifluoromethyl)benzenamine.

후처리

  1. additionadded over a period of 15-20 minutes at about 4° C
  2. customThe reaction mixture was then sealed in a polytetrafluoroethylene reactor
  3. temperaturemaintained
  4. customremoved

출처 및 근거

ORD 기록
ord-f2907788c7834689b5bc788e03074260
출처 데이터셋
uspto-grants-1984_11
특허 번호
US04481370

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