Azepane → 3-Azepan-1-ylpropan-1-ol
반응식
[NH:1]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[CH2:9][CH2:10][CH2:11][OH:12].[OH-].[K+]>C(O)C>[OH:12][CH2:11][CH2:10][CH2:9][N:1]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1참가 물질
5
실험 절차
A solution of 1 mole of azepane and 0.5 mole of 3-chloro-1-propanol in 500 ml of ethanol was refluxed for 18 hours. The reaction mixture was treated with 0.55 mole of KOH and refluxed for 0.75 hour. Cooling, filtration and distillation yielded 88% of N-(3-hydroxypropyl)azepane (b.p.=136° C. at 21 mm; analysis for C9H19NO, calculated: %N=8.91; found: %N=8.30).
후처리
- temperaturerefluxed for 0.75 hour
- temperatureCooling
- filtrationfiltration and distillation
출처 및 근거
- ORD 기록
- ord-8f3aa081a5ea49de891125a45b7c7581
- 출처 데이터셋
- uspto-grants-1984_11
- 특허 번호
- US04483833
반응 노트
불러오는 중…