Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanesulfonamide → p-Hexadecylamino-N-(methylsulfonyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanesulfonamide | HCID 72879 | — |
| 반응물 | 4-Hexadecylaminobenzoyl chloride hydrochloride | HCID 13255322 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | p-Hexadecylamino-N-(methylsulfonyl)benzamide | HCID 20437358 | — |
반응 단계
A solution of 25.2 g. of 4-(hexadecylamino)benzoyl chloride hydrochloride and 5.8 g. of methanesulfonamide in 250 ml. of pyridine was stirred under reflux for 2 hours and then concentrated in vacuo. The residue was partitioned between water and diethyl ether; the aqueous layer acidified with 1N HCl, and the organic layer separated, dried (MgSO4), and evaporated. Crystallization of the residual white solid from 60% aqueous acetic acid followed by CH2Cl2 -hexane afforded the product as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04485105 |
| 출처 데이터셋 | uspto-grants-1984_11 |
| ORD ID | ord-2d2a8bdcad684177ba8902cfe50d99d7 |
| 출처 메모 | uspto-grants-1984_11 |