Acetone → N-[4-(hexadecylamino)benzoyl]urea

HRID 1980170

반응식

HRID 1980170 반응식
Cl.[CH2:2]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[NH2:28][C:29]([NH2:31])=[O:30].[Na].CC(C)=O>C(Cl)Cl>[CH2:2]([NH:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH:28][C:29]([NH2:31])=[O:30])=[O:24])=[CH:21][CH:20]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

참가 물질

5

반응물 3

HCID 180AcetoneHCID 132553224-Hexadecylaminobenzoyl chloride hydrochlorideHCID 86736265Urea, monosodium salt

생성물 1

HCID 20437348N-[4-(hexadecylamino)benzoyl]urea

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The 12.6 g. of 4-(hexadecylamino)benzoyl chloride hydrochloride in methylene chloride is added to 5 g. of sodium urea in 30 ml. of acetone and the mixture is stirred at 20° C. for 18 hours. Dilute alkali is added and the solid washed with alkaline aqueous acetone. Recrystallization from ethanol gives pure white crystals of product.

후처리

  1. additionDilute
  2. additionalkali is added
  3. washthe solid washed with alkaline aqueous acetone
  4. customRecrystallization from ethanol
  5. customgives pure white crystals of product

출처 및 근거

ORD 기록
ord-1371bfa55e3a4669a4bcce4510ab2e23
출처 데이터셋
uspto-grants-1984_11
특허 번호
US04485105

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