Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → N-[4-(hexadecylamino)benzoyl]-2-aminoethanesulfonic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Taurine | HCID 1123 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | N-[N-trifluoroacetyl-4-(hexadecylamino)benzoyloxy]succinimide | HCID 20437360 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | N-[4-(hexadecylamino)benzoyl]-2-aminoethanesulfonic acid | HCID 20437369 | — |
반응 단계
To a stirred solution of 2.50 g. of taurine and 5.6 ml. of triethylamine in 22.5 ml. of water is added 5.55 g. of N-[p-(2,2,2-trifluoro-N-hexadecylacetamido)benzoyloxy]succinimide as a solution in 45 ml. of ethanol. After 24 hours, the mixture is treated with 20 ml. of 2.0M sodium hydroxide and 25 ml. of water. After stirring for 10 min., the mixture is acidified with dilute hydrochloric acid, and the crude product is collected by filtration. Recrystallization affords the title compound as a white solid, m.p. 190°-220° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04485105 |
| 출처 데이터셋 | uspto-grants-1984_11 |
| ORD ID | ord-4f1078d0a78644cfa4c9be30d442e760 |
| 출처 메모 | uspto-grants-1984_11 |