Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dicyclohexylcarbodiimide → N-[N-trifluoroacetyl-4-(hexadecylamino)benzoyloxy]succinimide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | N-Hydroxysuccinimide | HCID 80170 | — |
| 반응물 | N-trifluoroacetyl-4-(hexadecylamino)benzoic acid | HCID 20437350 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | N-[N-trifluoroacetyl-4-(hexadecylamino)benzoyloxy]succinimide | HCID 20437360 | — |
반응 단계
To a stirred ice-cold solution of 18.3 g. of p-(2,2,2-trifluoro-N-hexadecylacetamido)benzoic acid in 80 ml. of dioxane is added successively 4.84 g. of N-hydroxysuccinimide and 9.16 g. of dicylohexylcarbodiimide. After 18 hours at 0°-5° C. the mixture is stirred vigorously for one hour with hexane and water and filtered. The hexane layer is washed with water, dried over magnesium sulfate, and concentrated to give an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04485105 |
| 출처 데이터셋 | uspto-grants-1984_11 |
| ORD ID | ord-123a317fa24c47769f939d8663431f36 |
| 출처 메모 | uspto-grants-1984_11 |