Ammonium Hydroxide → 5-Oxopyrrolidine-2-carboxamide

HRID 1980247노트

반응식

HRID 1980247 반응식
[NH2:1][C@H:2]([C:10]([O:12]CC)=O)[CH2:3][CH2:4][C:5](OCC)=[O:6].[OH-].[NH4+:16]>>[NH:1]1[CH:2]([C:10]([NH2:16])=[O:12])[CH2:3][CH2:4][C:5]1=[O:6]

참가 물질

3

반응물 2

HCID 14923Ammonium HydroxideHCID 73961Glutamic acid diethyl ester

생성물 1

HCID 2204615-Oxopyrrolidine-2-carboxamide수율 78.6%

실험 절차

A mixture of 575 g diethyl glutamate and 700 ml concentrated ammonium hydroxide was stirred for 10 hours, and kept in the freezer at (-20° C.) for 5 hours. The resulting white crystalline solid was filtered, washed with 500 ml ethanol followed by 200 ml ether and dried in a vacuum oven at 70° C. for 16 hours to remove the water of crystallization giving 270 g (78.6%) of white crystalline 2-pyrrolidone-5-carboxamide.

후처리

  1. waitkept in the freezer at (-20° C.) for 5 hours
  2. filtrationThe resulting white crystalline solid was filtered
  3. washwashed with 500 ml ethanol
  4. customdried in a vacuum oven at 70° C. for 16 hours
  5. customto remove
  6. customthe water of crystallization

출처 및 근거

ORD 기록
ord-52a4d281a4d646c5969c417e73268cb5
출처 데이터셋
uspto-grants-1985_04
특허 번호
US04508725

반응 노트

불러오는 중…