Potassium Iodide → HCID 20402707, 화합물

HRID 1980264노트

반응식

HRID 1980264 반응식
[C:1]([C:9]1[C:10]([NH:16][C:17](=[O:20])[CH2:18]Cl)=[CH:11][N:12]([CH3:15])[C:13]=1[CH3:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I-:21].[K+]>C(O)C>[C:1]([C:9]1[C:10]([NH:16][C:17](=[O:20])[CH2:18][I:21])=[CH:11][N:12]([CH3:15])[C:13]=1[CH3:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 4875Potassium IodideHCID 20402708HCID 20402708, 화합물

생성물 1

HCID 20402707HCID 20402707, 화합물수율 87%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

N-(4-benzoyl-1,5-dimethyl(1H)pyrrol-3-yl)2-chloroacetamide (0.741 mole) and potassium iodide (1.62 mole) were refluxed in ethanol (3400 ml) for 5 hours with stirring. The reaction mixture was then cooled, the inorganic salts were filtered and the solvent was evaporated under vacuum. The obtained residue was purified by washing first with water and then with cold ethanol. M.p. 135°-137° C. Yield 87%.

후처리

  1. temperatureThe reaction mixture was then cooled
  2. filtrationthe inorganic salts were filtered
  3. customthe solvent was evaporated under vacuum
  4. customThe obtained residue was purified
  5. washby washing first with water

출처 및 근거

ORD 기록
ord-fc68db725e3742248918ab097b11d96b
출처 데이터셋
uspto-grants-1985_04
특허 번호
US04508730

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