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Diisopropyl Ether → HCID 13206546, 화합물

HRID 1980440
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HRID 1980440 반응식
[NH2:1][C:2]1[N:11]=[C:10]([O:12][CH3:13])[C:9]2[C:4](=[N:5][CH:6]=[CH:7][N:8]=2)[N:3]=1.[Cl:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[S:21]([N:24]=[C:25]=[O:26])(=[O:23])=[O:22].C(OC(C)C)(C)C>C(N(CC)CC)C.C(#N)C>[CH3:13][O:12][C:10]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][N:8]=2)[N:3]=[C:2]([NH:1][C:25]([NH:24][S:21]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[Cl:14])(=[O:22])=[O:23])=[O:26])[N:11]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 7914Diisopropyl EtherHCID 174071Benzenesulfonyl isocyanate, 2-chloro-HCID 2462834-Methoxypteridin-2-amine

생성물 1

HCID 13206546HCID 13206546, 화합물수율 87%

시약·촉매·용매 2

HCID 8471Triethylamine촉매HCID 6342Acetonitrile용매

실험 절차

1.5 g (0.0069 mol) of 2-amino-4-methoxypteridine and two drops of triethylamine were added to a mixture of 1.77 g (0.01 mol) of 2-chlorophenylsulfonyl isocyanate in 20 ml of acetonitrile and the mixture was refluxed for 30 minutes, cooled and mixed with diisopropyl ether. After standing for 10 minutes, the mixture was vacuum filtered to obtain 2.25 g (87% of theory) of N-(4-methoxypteridin-2-yl)-N'-(2-chlorophenylsulfonyl)-urea melting at 212° C.

후처리

  1. temperaturethe mixture was refluxed for 30 minutes
  2. temperaturecooled
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-b39d55fcc183422d8e5ffb6047752d74
출처 데이터셋
uspto-grants-1985_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04509972

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