Hydrazine → ethyl 2-[P-ethyl-2-hydroxyamino-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinyloxyimino]propionate

HRID 1980457노트

반응식

HRID 1980457 반응식
[CH2:1]([P:3]([C:14]1[CH:19]=[C:18]([O:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][C:22]=2[Cl:31])[CH:17]=[CH:16][C:15]=1[N+:32]([O-])=[O:33])([O:5][N:6]=[C:7]([CH3:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:4])[CH3:2].NN>O1CCCC1.[Rh]>[CH2:1]([P:3]([C:14]1[CH:19]=[C:18]([O:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]([F:29])([F:30])[F:28])=[CH:23][C:22]=2[Cl:31])[CH:17]=[CH:16][C:15]=1[NH:32][OH:33])([O:5][N:6]=[C:7]([CH3:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:4])[CH3:2]

참가 물질

5

반응물 2

HCID 9321HydrazineHCID 86740017ethyl 2-[P-ethyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinyloxyimino]propionate

생성물 1

HCID 86740016ethyl 2-[P-ethyl-2-hydroxyamino-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinyloxyimino]propionate

시약·촉매·용매 2

HCID 23948Rhodium촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of ethyl 2-[P-ethyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinyloxyimino]propionate (500 mg) in tetrahydrofuran (10 ml) is added hydrazine (1 eq.) and 5% rhodium on activated charcoal (50 mg) at 15°-25°, with stirring for 2 hours. The reaction is then filtered and the filtrate is diluted with methylene chloride, washed, dried and concentrated to dryness to give ethyl 2-[P-ethyl-2-hydroxyamino-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinyloxyimino]propionate.

후처리

  1. filtrationThe reaction is then filtered
  2. additionthe filtrate is diluted with methylene chloride
  3. washwashed
  4. customdried
  5. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-40e54f80e93c489bb294406d7e2b5d61
출처 데이터셋
uspto-grants-1985_04
특허 번호
US04509970

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