Ammonia → 7-Amino-3-chloroquinoline-8-carbonitrile
반응식
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7](Cl)[C:6]=2[C:13]#[N:14].[NH3:15]>CO>[NH2:15][C:7]1[C:6]([C:13]#[N:14])=[C:5]2[C:10]([CH:11]=[C:2]([Cl:1])[CH:3]=[N:4]2)=[CH:9][CH:8]=1참가 물질
4
실험 절차
110 g of 3,7-dichloro-8-cyanoquinoline, 500 ml of methanol and 500 ml of liquid ammonia were heated at 150° C. for 10 hours in an autoclave. The pressure was let down, after which the discharged mixture was filtered under suction, and the solid was recrystallized from methylglycol, in the presence of active charcoal. 54 g of 7-amino-3-chloro-8-cyanoquinoline of melting point 246° C. were obtained. Yield: 53% of theory.
후처리
- filtrationafter which the discharged mixture was filtered under suction
- customthe solid was recrystallized from methylglycol, in the presence of active charcoal
출처 및 근거
- ORD 기록
- ord-cb67630bef864498b6d418c5300bfc03
- 출처 데이터셋
- uspto-grants-1985_04
- 특허 번호
- US04511393
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