Hydrogen Peroxide → 4-(2-Hydroxyethoxy)phenol

HRID 1981061노트

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HRID 1981061 반응식
CC([C:4]1[CH:13]=[CH:12][C:7]([O:8][CH2:9][CH2:10][OH:11])=[CH:6][CH:5]=1)=C.OO.[OH:16]S(O)(=O)=O.[O-]S([O-])=O.[Na+].[Na+]>CO>[OH:11][CH2:10][CH2:9][O:8][C:7]1[CH:12]=[CH:13][C:4]([OH:16])=[CH:5][CH:6]=1

참가 물질

6

반응물 4

HCID 784Hydrogen PeroxideHCID 1118Sulfuric AcidHCID 24437Sodium SulfiteHCID 137506132-(4-(1-Methylethenyl)phenoxy)ethanol

생성물 1

HCID 98340144-(2-Hydroxyethoxy)phenol

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a mixture of 2.50 g 2-(4-(1-methylethenyl)phenoxy)ethanol, 10 ml methanol, and 1.1 equivalents 50% aqueous H2O2 were added 0.1 equivalent 98% H2SO4. The reaction mixture warmed itself to reflux which subsided in a few minutes. After addition of 0.2 equivalent Na2SO3, methanol was removed under reduced pressure. The residue was taken up in ether, dried over Na2SO4 and NaHCO3, and filtered. Removal of solvent left 4-(2-hydroxyethoxy)phenol in quantitative yield.

후처리

  1. temperatureThe reaction mixture warmed itself
  2. temperatureto reflux which
  3. waitsubsided in a few minutes
  4. customwas removed under reduced pressure
  5. dry with materialdried over Na2SO4 and NaHCO3
  6. filtrationfiltered
  7. customRemoval of solvent
  8. waitleft 4-(2-hydroxyethoxy)phenol in quantitative yield

출처 및 근거

ORD 기록
ord-370c9a8b03b54f87a46c2e069968cf21
출처 데이터셋
uspto-grants-1985_04
특허 번호
US04511731

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