Potassium Carbonate → 2-(2-Chloroethoxy)benzene-1-sulfonamide

HRID 1981251

반응식

HRID 1981251 반응식
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].C(=O)([O-])[O-].[K+].[K+].C1(C)C=CC(C(S(O[CH2:30][CH2:31][Cl:32])(=O)=O)=O)=CC=1>C(C(C)=O)C>[Cl:32][CH2:31][CH2:30][O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:9])=[O:10]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 6375462-Hydroxybenzene-1-sulfonamideHCID 539698672-Chloroethyl p-toloylsulfonate

생성물 1

HCID 137294542-(2-Chloroethoxy)benzene-1-sulfonamide

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

A mixture of 9.0 g of 2-hydroxyphenylsulfonamide, 7.9 g of potassium carbonate, 13.3 g of 2-chloroethyl p-toloylsulfonate and 80 ml of ethylmethylketone is refluxed for 40 hours. The reaction mixture is cooled to room temperature, filtrated and evaporated to dryness. From the oily residue crystallise after addition of a small portion of methylene chloride 7.0 g of 2-(2-chloroethoxy)-phenylsulfonamide, m.p. 110° C.

후처리

  1. temperatureis refluxed for 40 hours
  2. filtrationfiltrated
  3. customevaporated to dryness
  4. customFrom the oily residue crystallise
  5. additionafter addition of a small portion of methylene chloride 7.0 g of 2-(2-chloroethoxy)-phenylsulfonamide, m.p. 110° C.

출처 및 근거

ORD 기록
ord-2dd14a13353a49bf95478b95afaa1780
출처 데이터셋
uspto-grants-1985_04
특허 번호
US04514212

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