Imidazole → Climbazole

HRID 1981290

반응식

HRID 1981290 반응식
Br[CH:2]([O:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)[C:3](=[O:8])[C:4]([CH3:7])([CH3:6])[CH3:5].[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1.N1C=CN=C1C(C(C(C1NC=CN=1)=O)=O)=O.O>C(#N)C>[CH3:5][C:4]([C:3]([CH:2]([O:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)[N:17]1[CH:18]=[N:19][CH:20]=[CH:21]1)=[O:8])([CH3:7])[CH3:6]

참가 물질

6

반응물 4

HCID 795ImidazoleHCID 962WaterHCID 132691431-Bromo-1-(4-chlorophenoxy)-3,3-dimethylbutan-2-oneHCID 21924262HCID 21924262, 화합물

생성물 1

HCID 37907Climbazole

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

The antigingivitis agent utilized in present invention is 1-imidazoyl-(p-chlorophenoxy)3-3-dimethyl 2-butanone having the structural formula: ##STR2## which is prepared by reacting 1-bromo-1-(4-chlorophenoxy)-3,3-dimethyl-2-butanone with imidazole dissolved in acetonitrile as disclosed in U.S. Pat. Nos. 3,812,142 and 3,903,287, which is made a part of this specification. This imidazoyl ketone is a water insoluble crystalline powder having a melting point of 94.5°-97.8° C. which may be obtained from the Bayer Company as Climbazole. Due to the water insolubility of this imidazole compound, it must first be solubilized in a nonionic compound prior to the addition of ionic materials in an aqueous medium.

후처리

  1. custom##STR2## which is prepared

출처 및 근거

ORD 기록
ord-0c06c30f47d243f7943f6a72356ccafd
출처 데이터셋
uspto-grants-1985_04
특허 번호
US04514382

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