Undecanoyl chloride → 2-Trifluoromethyl-10-[3-(3-undecanoyloxypyrrolidino)-propyl]-phenothiazine

HRID 1981293노트

반응식

HRID 1981293 반응식
Cl.[F:2][C:3]([F:28])([F:27])[C:4]1[CH:17]=[CH:16][C:15]2[S:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[N:7]([CH2:18][CH2:19][CH2:20][N:21]3[CH2:25][CH2:24][CH:23]([OH:26])[CH2:22]3)[C:6]=2[CH:5]=1.[C:29](Cl)(=[O:40])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39]>>[F:28][C:3]([F:27])([F:2])[C:4]1[CH:17]=[CH:16][C:15]2[S:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[N:7]([CH2:18][CH2:19][CH2:20][N:21]3[CH2:25][CH2:24][CH:23]([O:26][C:29](=[O:40])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])[CH2:22]3)[C:6]=2[CH:5]=1

참가 물질

3

반응물 2

HCID 87287Undecanoyl chlorideHCID 16298210-(3-(3-Hydroxypyrrolidinyl)propyl)-2-trifluoromethylphenothiazine

생성물 1

HCID 203991662-Trifluoromethyl-10-[3-(3-undecanoyloxypyrrolidino)-propyl]-phenothiazine

실험 절차

According to the procedure of Example 5, 10.8 g of 2-trifluoromethyl-10-[3-(3-hydroxypyrrolidino)-propyl]-phenothiazine.hydrochloride and 6.2 g of undecanoylchloride were subjected to the reaction, to object the object as the free base. (Yield: 11.2 g)

후처리

  1. customwere subjected to the reaction

출처 및 근거

ORD 기록
ord-3ba16f6f5eb04b74bd681794a412e758
출처 데이터셋
uspto-grants-1985_04
특허 번호
US04514395

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