홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

4-Nitrophenyl 1-oxo-1lambda~5~-pyridine-3-carboxylate → N-[3-[3-(3-methylpiperidinomethyl)phenoxy]propyl]-3-pyridinecarboxamide 1-oxide

HRID 1981361
노트
인쇄 미리보기

반응식

HRID 1981361 반응식
[N+:1]1([O-:19])[CH:6]=[CH:5][CH:4]=[C:3]([C:7](OC2C=CC([N+]([O-])=O)=CC=2)=[O:8])[CH:2]=1.[CH3:20][CH:21]1[CH2:26][CH2:25][CH2:24][N:23]([CH2:27][C:28]2[CH:29]=[C:30]([CH:36]=[CH:37][CH:38]=2)[O:31][CH2:32][CH2:33][CH2:34][NH2:35])[CH2:22]1>CO>[CH3:20][CH:21]1[CH2:26][CH2:25][CH2:24][N:23]([CH2:27][C:28]2[CH:29]=[C:30]([CH:36]=[CH:37][CH:38]=2)[O:31][CH2:32][CH2:33][CH2:34][NH:35][C:7]([C:3]2[CH:2]=[N+:1]([O-:19])[CH:6]=[CH:5][CH:4]=2)=[O:8])[CH2:22]1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 133646764-Nitrophenyl 1-oxo-1lambda~5~-pyridine-3-carboxylateHCID 140261883-{3-[(3-Methylpiperidin-1-yl)methyl]phenoxy}propan-1-amine

생성물 1

HCID 6917813N-[3-[3-(3-methylpiperidinomethyl)phenoxy]propyl]-3-pyridinecarboxamide 1-oxide

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

To the active ester thus obtained there is added a solution of 3.8 g of 3-[3-(3-methylpiperidinomethyl)phenoxy]propylamine in 70 ml of methanol and the mixture is stirred 3 hours at 50° C. The solvent is evaporated, the residue is taken up with 30 ml of N hydrochloric acid and the acid solution is washed 3 times with 20 ml of ethyl acetate. The pH is adjusted to 7.8, then the solution is salted out with sodium chloride and extracted 6 times with 30 ml of ethyl acetate. The organic extracts are collected and dried over anhydrous sodium sulfate and the solvent in evaporated to dryness. The product is purified by chromatography on silica as described in Example 7. Thus, the N-[3-[3-(3-methylpiperidinomethyl)phenoxy]propyl]-3-pyridinecarboxamide 1-oxide is obtained, identical to the product of Example 8.

후처리

  1. customThe solvent is evaporated
  2. washthe acid solution is washed 3 times with 20 ml of ethyl acetate
  3. extractionextracted 6 times with 30 ml of ethyl acetate
  4. customThe organic extracts are collected
  5. dry with materialdried over anhydrous sodium sulfate
  6. customthe solvent in evaporated to dryness
  7. customThe product is purified by chromatography on silica

출처 및 근거

ORD 기록
ord-29b42e2237774cae9ea78342356694ea
출처 데이터셋
uspto-grants-1985_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04514408

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트