1-Propylboronic acid → N-(4-tert-butyl-benzyl)-3-chloro-2-fluoro-N-[2-(4-fluoro-3-propyl-phenyl)-ethyl]-5-trifluoromethyl-benzamide

HRID 19815

반응식

HRID 19815 반응식
Br[C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][N:11]([CH2:26][C:27]2[CH:32]=[CH:31][C:30]([C:33]([CH3:36])([CH3:35])[CH3:34])=[CH:29][CH:28]=2)[C:12](=[O:25])[C:13]2[CH:18]=[C:17]([C:19]([F:22])([F:21])[F:20])[CH:16]=[C:15]([Cl:23])[C:14]=2[F:24])[CH:5]=[CH:6][C:7]=1[F:8].[CH2:37](B(O)O)[CH2:38][CH3:39]>>[C:33]([C:30]1[CH:31]=[CH:32][C:27]([CH2:26][N:11]([CH2:10][CH2:9][C:4]2[CH:5]=[CH:6][C:7]([F:8])=[C:2]([CH2:37][CH2:38][CH3:39])[CH:3]=2)[C:12](=[O:25])[C:13]2[CH:18]=[C:17]([C:19]([F:20])([F:21])[F:22])[CH:16]=[C:15]([Cl:23])[C:14]=2[F:24])=[CH:28][CH:29]=1)([CH3:34])([CH3:36])[CH3:35]

참가 물질

3

반응물 2

HCID 3510651-Propylboronic acidHCID 86613996N-[2-(3-bromo-4-fluoro-phenyl)-ethyl]-N-(4-tert-butyl-benzyl)-3-chloro-2-fluoro-5-trifluoromethyl-benzamide

생성물 1

HCID 86613997N-(4-tert-butyl-benzyl)-3-chloro-2-fluoro-N-[2-(4-fluoro-3-propyl-phenyl)-ethyl]-5-trifluoromethyl-benzamide

실험 절차

The title compound was prepared in analogy to example 3, using N-[2-(3-bromo-4-fluoro-phenyl)-ethyl]-N-(4-tert-butyl-benzyl)-3-chloro-2-fluoro-5-trifluoromethyl-benzamide (Example B178) and n-propylboronic acid. 552.2 [ISP (M+H)+]

출처 및 근거

ORD 기록
ord-7f070b2d7d124deb9984c32232edf153
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745477B2

연결된 노트

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