1-Methyl-6-phenylpyrimidine-2,4(1H,3H)-dione → 1-Methyl-6-phenyldihydropyrimidine-2,4(1H,3H)-dione

HRID 1981523노트

반응식

HRID 1981523 반응식
[CH3:1][N:2]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:8][C:6](=[O:7])[NH:5][C:3]1=[O:4]>CN(C)C=N.[Pd]>[CH3:1][N:2]1[CH:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:8][C:6](=[O:7])[NH:5][C:3]1=[O:4]

참가 물질

4

반응물 1

HCID 123003501-Methyl-6-phenylpyrimidine-2,4(1H,3H)-dione

생성물 1

HCID 130862351-Methyl-6-phenyldihydropyrimidine-2,4(1H,3H)-dione

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 12669390N,N-Dimethylmethanimidamide용매

실험 절차

A solution of 1-methyl-6-phenyluracil (0.65 g) in dimethylformamidine (15 ml) is treated with 10 percent palladium on carbon and reduced at 40 p.s.i. for 20 hours. The catalyst is then filtered and the filtrate evaporated to a crystalline residue. The crystallization from acetonitrile provides 5,6-dihydro-1-methyl-6-phenyl-2,4-pyrimidine-dione, m.p. 155°-6° C.

후처리

  1. filtrationThe catalyst is then filtered
  2. customthe filtrate evaporated to a crystalline residue
  3. customThe crystallization from acetonitrile

출처 및 근거

ORD 기록
ord-d5529b8924f647c39cec7efb51d97390
출처 데이터셋
uspto-grants-1986_06
특허 번호
US04593030

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