3-Trifluoromethyl-4'-benzyloxy-alpha-ethyl-benzhydrol → 3-Trifluoromethyl-4'-hydroxy-alpha-ethylbenzhydrol

HRID 1981558

반응식

HRID 1981558 반응식
[F:1][C:2]([F:28])([F:27])[C:3]1[CH:4]=[C:5]([CH:24]=[CH:25][CH:26]=1)[C:6]([CH2:22][CH3:23])([OH:21])[C:7]1[CH:12]=[CH:11][C:10]([O:13]CC2C=CC=CC=2)=[CH:9][CH:8]=1.[H][H]>[Pd].CO>[F:1][C:2]([F:27])([F:28])[C:3]1[CH:4]=[C:5]([CH:24]=[CH:25][CH:26]=1)[C:6]([CH2:22][CH3:23])([OH:21])[C:7]1[CH:8]=[CH:9][C:10]([OH:13])=[CH:11][CH:12]=1

참가 물질

5

반응물 2

HCID 202398663-Trifluoromethyl-4'-benzyloxy-alpha-ethyl-benzhydrolHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 1818763-Trifluoromethyl-4'-hydroxy-alpha-ethylbenzhydrol

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

54.1 g. of 3-trifluoromethyl-4'-benzyloxy-α-ethyl-benzhydrol in 541 ml. of methanol are hydrogenated under atmospheric pressure, in the presence of 27.1 g. of a 10% palladium-on-charcoal catalyst. When the uptake of the calculated amount of hydrogen is complete, the catalyst is filtered off, and the solvent is distilled off under reduced pressure. The crude product is decoloured with charcoal in ethyl acetate, and recrystallized from a mixture of ethyl acetate and n-hexane. 30.8 g. of the named compound are obtained, melting at 102.5° to 103° C.

후처리

  1. filtrationthe catalyst is filtered off
  2. distillationthe solvent is distilled off under reduced pressure
  3. customrecrystallized from a mixture of ethyl acetate and n-hexane
  4. customof the named compound are obtained

출처 및 근거

ORD 기록
ord-7fc03fb4c9b04d1a902be11de0f1e52a
출처 데이터셋
uspto-grants-1986_06
특허 번호
US04593047

연결된 노트

불러오는 중…