Fuming sulfuric acid → Sulfuric Acid

HRID 1981596

반응식

HRID 1981596 반응식
ClC1C=C(C=CC=1)NCCC(O)=O.ClC1C=C2C(C(=O)CCN2)=CC=1.[OH:26][S:27]([OH:30])(=[O:29])=[O:28].O=S(=O)=O.F.[B:36]([F:39])([F:38])[F:37]>>[S:27](=[O:28])(=[O:26])([OH:30])[OH:29].[FH:37].[B:36]([F:39])([F:38])[F:37]

참가 물질

7

반응물 4

HCID 24681Fuming sulfuric acidHCID 889747-Chloro-2,3-dihydro-4-quinoloneHCID 9855450Trifluoroborane HydrofluorideHCID 124709193-((3-Chlorophenyl)amino)propanoic acid

생성물 3

HCID 1118Sulfuric AcidHCID 6356Boron trifluorideHCID 14917Hydrofluoric Acid

실험 절차

It should, however, be noted that, in the particular case of the cyclisation of 3-(m-chloroanilino)-propionic acid by polyphosphoric acid, a mixture of substantially equal quantities of 5-chloro- and 7-chloro-1,2,3,4-tetrahydro-4-quinolinone is obtained. The selectivity for 7-chloro-1,2,3,4-tetrahydro-4-quinolinone is significantly improved if an oleum or a hydrofluoric acid/boron trifluoride mixture is used as cyclisation agent, but the industrial use of these processes encounters difficulties which result either from the handling of large quantities of sulphuric acid or from the utilisation of a mixture of anhydrous hydrofluoric acid and boron trifluoride.

후처리

  1. customis obtained

출처 및 근거

ORD 기록
ord-5e819d090e934416b6a5282c4fb537b0
출처 데이터셋
uspto-grants-1986_06
특허 번호
US04593101

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