Acetamide, 2-chloro-N-(chloromethyl)-N-(2-ethyl-6-methylphenyl)- → 2-chloro-2'-methyl-6'-ethyl-N-(4-chloro-3,5-dimethylpyrazol-1-yl-methyl)-acetanilide

HRID 1981603노트

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HRID 1981603 반응식
[Cl:1][CH2:2][C:3]([N:5]([CH2:15]Cl)[C:6]1[C:11]([CH2:12][CH3:13])=[CH:10][CH:9]=[CH:8][C:7]=1[CH3:14])=[O:4].[Cl:17][C:18]1[C:19]([CH3:24])=[N:20][NH:21][C:22]=1[CH3:23]>COCCOC>[Cl:1][CH2:2][C:3]([N:5]([CH2:15][N:20]1[C:19]([CH3:24])=[C:18]([Cl:17])[C:22]([CH3:23])=[N:21]1)[C:6]1[C:11]([CH2:12][CH3:13])=[CH:10][CH:9]=[CH:8][C:7]=1[CH3:14])=[O:4]

참가 물질

4

반응물 2

HCID 180581Acetamide, 2-chloro-N-(chloromethyl)-N-(2-ethyl-6-methylphenyl)-HCID 6736884-chloro-3,5-dimethyl-1H-pyrazole

생성물 1

HCID 130699242-chloro-2'-methyl-6'-ethyl-N-(4-chloro-3,5-dimethylpyrazol-1-yl-methyl)-acetanilide

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

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온도
0 °C

실험 절차

21.4 parts by weight of 2-chloro-2'-methyl-6'-ethyl-N-chloromethyl acetanilide and 20.2 parts by weight of 4-chloro-3,5-dimethylpyrazole are refluxed for 10 hours in 100 parts by volume of glycol dimethyl ether. After cooling the mixture to 0° C., it is filtered, and the filtrate, concentrated to 23.8 parts by weight, is filtered with 600 parts by volume of chloroform through 50 parts by weight of silica gel. From the concentrated chloroform filtrate there is isolated 20.4 parts by weight of 2-chloro-2'-methyl-6'-ethyl-N-(4-chloro-3,5-dimethylpyrazol-1-yl-methyl)-acetanilide as an oil which completely crystallizes upon milling with 50 ml of petroleum ether (m.p. 66° C. from petroleum ether).

후처리

  1. filtrationit is filtered
  2. concentrationthe filtrate, concentrated to 23.8 parts by weight
  3. filtrationis filtered with 600 parts by volume of chloroform through 50 parts by weight of silica gel

출처 및 근거

ORD 기록
ord-c1f449e4e8f649f4b4bf9c686a4df531
출처 데이터셋
uspto-grants-1986_06
특허 번호
US04593104

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