Batelapine → 2-methyl-5-(4-methyl-4-oxido-1-piperazinyl)-11H-1,2,4-triazolo[2,3-c][1,3]benzodiazepine
반응식
[CH3:1][C:2]1[N:3]=[C:4]2[CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[N:7]=[C:6]([N:15]3[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]3)[N:5]2[N:22]=1.ClC1C=CC=C(C(OO)=[O:31])C=1>C(Cl)Cl>[CH3:1][C:2]1[N:3]=[C:4]2[CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[N:7]=[C:6]([N:15]3[CH2:16][CH2:17][N+:18]([CH3:21])([O-:31])[CH2:19][CH2:20]3)[N:5]2[N:22]=1참가 물질
4
실험 절차
To a solution of 5 g of 2-methyl-5-(4-methyl-1-piperazinyl)-11H-1,2,4-triazolo[2,3-c][1,3]benzodiazepine in 50 ml of methylene chloride is added in portions 3.75 g of m-chloroperbenzoic acid with stirring at 0°. The mixture is then stirred at room temperature overnight and evaporated to dryness. The foamy residue is passed through 100 g of Amberlite IRA-400 ion exchange resin using water as eluent. Evaporation of the eluent gives 2-methyl-5-(4-methyl-4-oxido-1-piperazinyl)-11H-1,2,4-triazolo[2,3-c][1,3]benzodiazepine.