Diketene → 2-[4-(2-Benzyloxyethoxy)phenyl]ethylacetoacetate
반응식
[OH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:6][CH:5]=1.[CH2:21]=[C:22]1[O:26][C:24](=[O:25])[CH2:23]1>>[CH2:14]([O:13][CH2:12][CH2:11][O:10][C:7]1[CH:8]=[CH:9][C:4]([CH2:3][CH2:2][O:1][C:24](=[O:25])[CH2:23][C:22]([CH3:21])=[O:26])=[CH:5][CH:6]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1참가 물질
3
실험 절차
Diketene (3-buteno-β-lactone, available, e.g., from Aldrich Chemical Co.) is then added to the hydroxyalkylbenzene derivative 4 under basic conditions, e.g., using triethylamine in dimethoxyethane (DME) to form a ω-phenylalkylacetoacetate derivative (5). For example, 1-(2-hydroxyethyl)-4-(2-benzyloxyethoxy)benzene is reacted with diketene to afford 2-[4-(2-benzyloxyethoxy)phenyl]ethylacetoacetate (5). (Step 5.)
출처 및 근거
- ORD 기록
- ord-592559b2693846dc90b6ac3f461ae3df
- 출처 데이터셋
- uspto-grants-1986_06