Water → N-(2-Oxo-1-phenylpropyl)hexanamide

HRID 1982436노트

반응식

HRID 1982436 반응식
Cl.[NH2:2][CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4](=[O:6])[CH3:5].O.C(=O)([O-])[O-].[K+].[K+].[C:20](Cl)(=[O:26])[CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>C(OCC)(=O)C>[C:20]([NH:2][CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4](=[O:6])[CH3:5])(=[O:26])[CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 67340Hexanoyl chlorideHCID 27970031-amino-1-phenylpropan-2-one hydrochloride

생성물 1

HCID 13293301N-(2-Oxo-1-phenylpropyl)hexanamide

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a mixture of 1-amino-1-phenyl-2-propanone hydrochloride (5.55 g), water (40 ml), ethyl acetate (75 ml) and potassium carbonate (4.55 g) was added dropwise hexanoyl chloride (4.42 g) under ice-cooling and stirring. The mixture was further stirred for an hour with ice-cooling. The ethyl acetate layer was separated, washed with water, diluted hydrochloric acid and water in that order, and dried over anhydrous magnesium sulfate. The solvent was then distilled off and the residue was recrystallized from isopropyl ether to give crystals of 1-hexanoylamino-1-phenyl-2-propanone, yield 5.80 g (78.2%), m.p. 77°-78° C.

후처리

  1. temperaturecooling
  2. stirringThe mixture was further stirred for an hour with ice-
  3. temperaturecooling
  4. customThe ethyl acetate layer was separated
  5. washwashed with water, diluted hydrochloric acid and water in that order
  6. dry with materialdried over anhydrous magnesium sulfate
  7. distillationThe solvent was then distilled off
  8. customthe residue was recrystallized from isopropyl ether

출처 및 근거

ORD 기록
ord-839689b51daf449195babcbe1f0eb571
출처 데이터셋
uspto-grants-1986_06
특허 번호
US04596816

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