Potassium Carbonate → HCID 13633265, 화합물

HRID 1982527노트

반응식

HRID 1982527 반응식
[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]([N+:13]([O-:15])=[O:14])[CH:7]=2)=[O:5])[CH2:3][CH2:2]1.[BrH:16].C(O)(=O)C.C(=O)([O-])[O-].[K+].[K+]>C(O)(=O)C>[Br:16][CH2:3][CH2:2][CH2:1][C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]([N+:13]([O-:15])=[O:14])[CH:7]=1)=[O:5]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 12682594-Chloro-3-nitrophenyl cyclopropyl ketoneHCID 21893785Acetic Acid Mixture with Hydrobromic Acid

생성물 1

HCID 13633265HCID 13633265, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
80 °C

실험 절차

20 g (88.6 mmol) of 4-chloro-3-nitrophenyl cyclopropyl ketone is added to a solution of 65 m of 32% HBr/acetic acid in 300 ml acetic acid and heated to 80° C. for 5 hr. The reaction mixture is cooled to room temperature and poured nto 1 L of 10% potassium carbonate solution, dried over MgSO4 filtered and treated with charcoal. The solvent is removed in vacuo, and the residue is crystallized from ether to provide the title compound.

후처리

  1. temperatureThe reaction mixture is cooled to room temperature
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. additiontreated with charcoal
  5. customThe solvent is removed in vacuo
  6. customthe residue is crystallized from ether

출처 및 근거

ORD 기록
ord-a4f60d8f66334188b2393a08d693cf29
출처 데이터셋
uspto-grants-1986_06
특허 번호
US04596872

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