8-(4-Chlorophenyl)-5,6-dihydroimidazo[1,2-a]pyridine → Imidazo[1,2-a]pyridine,8-(4-chlorophenyl)-
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[N:10]([CH:14]=[CH:15][N:16]=3)[CH2:11][CH2:12][CH:13]=2)=[CH:4][CH:3]=1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]3[N:10]([CH:14]=[CH:15][N:16]=3)[CH:11]=[CH:12][CH:13]=2)=[CH:6][CH:7]=1참가 물질
4
실험 절차
Combine 30 g (0.12 mol) of the product from Example 1 with 150 g of "activated" manganese dioxide in 500 ml of methylene chloride, and heat to reflux for 6 hr. Filter off the solids and remove the solvent in vacuo. The residue is crystallized from ether to provide the title compound.
후처리
- temperatureto reflux for 6 hr
- filtrationFilter off the solids
- customremove the solvent in vacuo
- customThe residue is crystallized from ether
출처 및 근거
- ORD 기록
- ord-9bbca1952d9c44b092c649958a95a177
- 출처 데이터셋
- uspto-grants-1986_06
- 특허 번호
- US04596872
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