Cyclohexene → 1-Chloromethyl-5-chloropyrimidin-2-one

HRID 1982552

반응식

HRID 1982552 반응식
S(Cl)([Cl:4])(=O)=O.ClC1C=CC(S[CH2:14][N:15]2[CH:20]=[C:19]([Cl:21])[CH:18]=[N:17][C:16]2=[O:22])=CC=1.C1CCCCC=1>ClCCl>[Cl:4][CH2:14][N:15]1[CH:20]=[C:19]([Cl:21])[CH:18]=[N:17][C:16]1=[O:22]

참가 물질

5

반응물 3

HCID 8079CyclohexeneHCID 24648Sulfuryl chlorideHCID 42952761-(4-Chlorophenylsulfenyl)methyl-5-chloropyrimidin-2-one

생성물 1

HCID 201613341-Chloromethyl-5-chloropyrimidin-2-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매3회

실험 절차

Sulphuryl chloride (3.0 mmol) in dry dichloromethane (10.0 ml) was added to 1-(4-chlorophenylsulphenyl) methyl-5-chloropyrimidin-2-one (see Example 2) (3.0 mmol) in dry dichlormethane 30.0 ml) at -30° C. for 3 mins. The mixture was stirred at -25° C. for 50 mins before cyclohexene (3.5 mmol) in dry dichloromethane (10 ml) was added. After stirring for 15 mins the mixture was filtered, evaporated and the residue washed three times with Pet. ether. Insoluble 1-chloromethyl-5-chloropyrimidin-2-one (0.45g), 84% was used in Example 31 without further purification.

후처리

  1. additionwas added
  2. filtrationwas filtered
  3. customevaporated
  4. washthe residue washed three times with Pet. ether
  5. customInsoluble 1-chloromethyl-5-chloropyrimidin-2-one (0.45g), 84% was used in Example 31 without further purification

출처 및 근거

ORD 기록
ord-bb22960df29948dab85e7f975306220b
출처 데이터셋
uspto-grants-1986_06
특허 번호
US04596870

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