Formaldehyde → [3-(propan-2-yl)-1H-pyrazol-1-yl]methanol

HRID 1982993노트

반응식

HRID 1982993 반응식
[CH:1]([C:4]1[CH:8]=[CH:7][NH:6][N:5]=1)([CH3:3])[CH3:2].[CH2:9]=[O:10].C(N(CC)CC)C>CC(C)=O>[CH:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9][OH:10])[N:5]=1)([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 712FormaldehydeHCID 8471TriethylamineHCID 178439403HCID 178439403, 화합물

생성물 1

HCID 23149190[3-(propan-2-yl)-1H-pyrazol-1-yl]methanol수율 87.5%

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
130 °C

실험 절차

The mixture of 1.15 g of 3-i-propyl-1H-pyrazole, 0.94 g of paraformaldehyde and 0.14 g of triethylamine was stirred at 130° C. for 7 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. The filterate was concentrated under reduced pressure. Hexane was added to the residue, and then crystalline was formed. The crystalline was collected to obtain 1.28 g of 3-i-propyl-1H-pyrazole-1-ylmethanol.

후처리

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. concentrationThe filterate was concentrated under reduced pressure
  4. additionHexane was added to the residue
  5. customcrystalline was formed
  6. customThe crystalline was collected

출처 및 근거

ORD 기록
ord-eeae46a0051743e3a770b198ff9cba6f
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541374B2

반응 노트

불러오는 중…