Formaldehyde → 1-(Hydroxymethyl)-1H-pyrazole-3-carbonitrile

HRID 1983003노트

반응식

HRID 1983003 반응식
[C:1]([C:3]1[CH:7]=[CH:6][NH:5][N:4]=1)#[N:2].[CH2:8]=[O:9]>CC(C)=O>[OH:9][CH2:8][N:5]1[CH:6]=[CH:7][C:3]([C:1]#[N:2])=[N:4]1

참가 물질

4

반응물 2

HCID 712FormaldehydeHCID 178510229HCID 178510229, 화합물

생성물 1

HCID 231492041-(Hydroxymethyl)-1H-pyrazole-3-carbonitrile수율 78.2%

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
130 °C

실험 절차

The mixture of 0.86 g of 3-cyano-1H-pyrazole and 0.55 g of paraformaldehyde was stirred at 130° C. for 7 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. After the mixture was filtered, the filterate was concentrated under reduced pressure to obtain 0.89 g of 1-(hydroxymethyl)-3-cyano-1H-pyrazole.

후처리

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationAfter the mixture was filtered
  3. concentrationthe filterate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-b89ab9f59ab34374bd4b9245c26fa816
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541374B2

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