Thionyl Chloride → 1-(chloromethyl)-3-cyano-1H-pyrazole

HRID 1983004노트

반응식

HRID 1983004 반응식
O[CH2:2][N:3]1[CH:7]=[CH:6][C:5]([C:8]#[N:9])=[N:4]1.S(Cl)([Cl:12])=O>ClCCl>[C:8]([C:5]1[CH:6]=[CH:7][N:3]([CH2:2][Cl:12])[N:4]=1)#[N:9]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 231492041-(Hydroxymethyl)-1H-pyrazole-3-carbonitrile

생성물 1

HCID 231491551-(chloromethyl)-3-cyano-1H-pyrazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

0.89 g of 1-(hydroxymethyl)-3-cyano-1H-pyrazole was dissolved to 30 ml of dichloromethane. 1.6 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.00 g of 3-cyano-1-(chloromethyl)-1H-pyrazole.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4048f98994ec4a3f9dab9965e6aea239
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541374B2

반응 노트

불러오는 중…