Thionyl Chloride → 1-(chloromethyl)-3-phenyl-1H-pyrazole hydrochloride

HRID 1983006노트

반응식

HRID 1983006 반응식
[C:1]1([C:7]2[CH:11]=[CH:10][N:9]([CH2:12]O)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:16])=O>ClCCl>[ClH:16].[Cl:16][CH2:12][N:9]1[CH:10]=[CH:11][C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[N:8]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 23149203(3-phenyl-1H-pyrazol-1-yl)methanol

생성물 1

HCID 231491981-(chloromethyl)-3-phenyl-1H-pyrazole hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1.74 g of 3-phenyl-1H-pyrazole-1-ylmethanol was dissolved to 50 ml of dichloromethane. 3.4 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure. Hexane and chloroform was added to the residue to produce a crystal. The crystal was collected to obtain 2.01 g of 1-(chloromethyl)-3-phenyl-1H-pyrazole hydrochloride.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionHexane and chloroform was added to the residue
  3. customto produce a crystal
  4. customThe crystal was collected

출처 및 근거

ORD 기록
ord-9e26bc2e22b947a69d9be7f84f70836b
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541374B2

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