Formaldehyde → 4-bromo-3-t-butyl-1H-pyrazole-1-ylmethanol
반응식
[Br:1][C:2]1[C:3]([C:7]([CH3:10])([CH3:9])[CH3:8])=[N:4][NH:5][CH:6]=1.[CH2:11]=[O:12]>C(N(CC)CC)C.CC(C)=O>[Br:1][C:2]1[C:3]([C:7]([CH3:10])([CH3:9])[CH3:8])=[N:4][N:5]([CH2:11][OH:12])[CH:6]=1참가 물질
5
반응 조건
- 온도
- 130 °C
실험 절차
The mixture of 3.14 g of 4-bromo-3-t-butyl-1H-pyrazole, 0.93 g of paraformaldehyde and 0.11 g of triethylamine was stirred at 130° C. for 7 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. Hexane was added to the residue obtained by concentration of the filtrate under reduced pressure, as a result, a crystal was formed. The crystal was collected to obtain 3.79 g of 4-bromo-3-t-butyl-1H-pyrazole-1-ylmethanol.
후처리
- temperatureAfter the reaction mixture was cooled to room temperature
- filtrationThe mixture was filtered
- additionHexane was added to the residue
- customobtained by concentration of the filtrate under reduced pressure, as a result
- customa crystal was formed
- customThe crystal was collected
출처 및 근거
- ORD 기록
- ord-db0ca102a1c24264b3da0eab9fcbad8a
- 출처 데이터셋
- uspto-grants-2009_06
- 특허 번호
- US07541374B2
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