Thionyl Chloride → 4-bromo-3-t-butyl-1-(chloromethyl)-1H-pyrazole hydrochloride

HRID 1983012노트

반응식

HRID 1983012 반응식
[Br:1][C:2]1[C:3]([C:9]([CH3:12])([CH3:11])[CH3:10])=[N:4][N:5]([CH2:7]O)[CH:6]=1.S(Cl)([Cl:15])=O>ClCCl>[ClH:15].[Br:1][C:2]1[C:3]([C:9]([CH3:12])([CH3:11])[CH3:10])=[N:4][N:5]([CH2:7][Cl:15])[CH:6]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 231491454-bromo-3-t-butyl-1H-pyrazole-1-ylmethanol

생성물 1

HCID 231491914-bromo-3-t-butyl-1-(chloromethyl)-1H-pyrazole hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3.79g of 4-bromo-3-t-butyl-1H-pyrazole-1-ylmethanol was dissolved to 45 ml of dichloromethane. 3.4 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure. The solid obtained was washed with hexane and chloroform to obtain 3.69 g of 4-bromo-3-t-butyl-1-(chloromethyl)-1H-pyrazole hydrochloride.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customThe solid obtained
  3. washwas washed with hexane and chloroform

출처 및 근거

ORD 기록
ord-56fd97145ef649b2b0011fc8590641ef
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541374B2

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