Formaldehyde → 4-bromo-3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol

HRID 1983017노트

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HRID 1983017 반응식
[Br:1][C:2]1[C:3]([C:7]([F:10])([F:9])[F:8])=[N:4][NH:5][CH:6]=1.[CH2:11]=[O:12]>CC(C)=O>[Br:1][C:2]1[C:3]([C:7]([F:10])([F:9])[F:8])=[N:4][N:5]([CH2:11][OH:12])[CH:6]=1

참가 물질

4

반응물 2

HCID 712FormaldehydeHCID 178506296HCID 178506296, 화합물

생성물 1

HCID 231491424-bromo-3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol수율 85.1%

시약·촉매·용매 1

HCID 180Acetone용매

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온도
140 °C

실험 절차

The mixture of 3.38 g of 4-bromo-3-(trifluoromethyl)-1H-pyrazole and 0.66 g of paraformaldehyde was stirred at 140° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. Hexane was added to the residue obtained by concentration of the filtrate under reduced pressure, as a result, a crystal was formed. The crystal was collected to obtain 3.28 g of 4-bromo-3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol.

후처리

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. additionHexane was added to the residue
  4. customobtained by concentration of the filtrate under reduced pressure, as a result
  5. customa crystal was formed
  6. customThe crystal was collected

출처 및 근거

ORD 기록
ord-f662bb82c3de4544a643ac2e08139b7e
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541374B2

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