Thionyl Chloride → 4-bromo-1-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole

HRID 1983018노트

반응식

HRID 1983018 반응식
[Br:1][C:2]1[C:3]([C:9]([F:12])([F:11])[F:10])=[N:4][N:5]([CH2:7]O)[CH:6]=1.S(Cl)([Cl:15])=O>ClCCl>[Br:1][C:2]1[C:3]([C:9]([F:12])([F:11])[F:10])=[N:4][N:5]([CH2:7][Cl:15])[CH:6]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 231491424-bromo-3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol

생성물 1

HCID 231491474-bromo-1-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3.28 g of 4-bromo-3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol was dissolved to 40 ml of dichloromethane. 2.9 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure. The obtained solid was washed with the mixture of hexane and chloroform to obtain 3.33 g of 4-bromo-1-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washThe obtained solid was washed with the mixture of hexane and chloroform

출처 및 근거

ORD 기록
ord-744ce6921e4a47f9907faf0034c55224
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541374B2

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