Thionyl Chloride → 4-chloro-1-(chloromethyl)-1H-pyrazole hydrochloride

HRID 1983021노트

반응식

HRID 1983021 반응식
[Cl:1][C:2]1[CH:3]=[N:4][N:5]([CH2:7]O)[CH:6]=1.S(Cl)([Cl:11])=O>ClCCl>[ClH:1].[Cl:1][C:2]1[CH:3]=[N:4][N:5]([CH2:7][Cl:11])[CH:6]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 7017837(4-chloro-1H-pyrazol-1-yl)methanol

생성물 1

HCID 231491194-chloro-1-(chloromethyl)-1H-pyrazole hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2.73 g of 4-chloro-1H-pyrazole-1-ylmethanol was dissolved to 20 ml of dichloromethane. 4.4 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 2.90 g of 4-chloro-1-(chloromethyl)-1H-pyrazole hydrochloride.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4ba79de6830f453fbdf6b7841f6f2834
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541374B2

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