Formaldehyde → 4-(Trifluoromethyl)-1H-pyrazole-1-methanol

HRID 1983023노트

반응식

HRID 1983023 반응식
[F:1][C:2]([F:9])([F:8])[C:3]1[CH:4]=[N:5][NH:6][CH:7]=1.[CH2:10]=[O:11]>CC(C)=O>[F:1][C:2]([F:9])([F:8])[C:3]1[CH:4]=[N:5][N:6]([CH2:10][OH:11])[CH:7]=1

참가 물질

4

반응물 2

HCID 712FormaldehydeHCID 127777954-(Trifluoromethyl)-1H-pyrazole

생성물 1

HCID 231491674-(Trifluoromethyl)-1H-pyrazole-1-methanol수율 83.3%

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
130 °C

실험 절차

The mixture of 0.59 g of 4-(trifluoromethyl)-1H-pyrazole and 0.26 g of paraformaldehyde was stirred at 130° C. for 4 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. The residue was concentration under reduced pressure to obtain 0.60 g of 4-(trifluoromethyl)-1H-pyrazole-1-ylmethanol.

후처리

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. concentrationconcentration under reduced pressure

출처 및 근거

ORD 기록
ord-f77e9e4b74ab44bf8ad91cda84084c59
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541374B2

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