Formaldehyde → 1-(Hydroxymethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole

HRID 1983037노트

반응식

HRID 1983037 반응식
[F:1][C:2]([F:9])([F:8])[C:3]1[N:7]=[CH:6][NH:5][N:4]=1.[CH2:10]=[O:11]>CC(C)=O>[F:1][C:2]([F:9])([F:8])[C:3]1[N:7]=[CH:6][N:5]([CH2:10][OH:11])[N:4]=1

참가 물질

4

반응물 2

HCID 712FormaldehydeHCID 178506277HCID 178506277, 화합물

생성물 1

HCID 231491401-(Hydroxymethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole수율 94.3%

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
150 °C

실험 절차

The mixture of 2.74 g of 3-(trifluoromethyl)-1H-1,2,4-triazole and 1.20 g of paraformaldehyde was stirred at 150° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture, and the mixture was filtered. The filtrate was concentrated. The residue was subjected to silica gel column chromatography to obtain 3.15 g of 3-(trifluoromethyl)-1H-1,2,4-triazole 1-ylmethanol.

후처리

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationthe mixture was filtered
  3. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-62a792cdb76445bc966e229dbf830580
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541374B2

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