Thionyl Chloride → 1-(chloromethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole

HRID 1983038노트

반응식

HRID 1983038 반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[N:7]=[CH:6][N:5]([CH2:8]O)[N:4]=1.S(Cl)([Cl:14])=O>ClCCl>[Cl:14][CH2:8][N:5]1[CH:6]=[N:7][C:3]([C:2]([F:11])([F:10])[F:1])=[N:4]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 231491401-(Hydroxymethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole

생성물 1

HCID 231491371-(chloromethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1.52 g of 3-(trifluoromethyl)-1H-1,2,4-triazole 1-ylmethanol was dissolved to 50 ml of dichloromethane, and 2.7 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.36 g of 1-(chloromethyl)-3-(trifluoromethyl)-1H-1,2,4-triazole.

후처리

  1. additionwas added to the solution
  2. concentrationThe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-78c4601423424f22baf8de452c249ad8
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541374B2

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