Formaldehyde → 3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol

HRID 1983042노트

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HRID 1983042 반응식
[F:1][C:2]([F:12])([C:7]1[CH:11]=[CH:10][NH:9][N:8]=1)[C:3]([F:6])([F:5])[F:4].[CH2:13]=[O:14]>CC(C)=O>[F:12][C:2]([F:1])([C:7]1[CH:11]=[CH:10][N:9]([CH2:13][OH:14])[N:8]=1)[C:3]([F:6])([F:5])[F:4]

참가 물질

4

반응물 2

HCID 712FormaldehydeHCID 1785063263-(pentafluoroethyl)-1H-pyrazole

생성물 1

HCID 231491363-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol수율 91.7%

시약·촉매·용매 1

HCID 180Acetone용매

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온도
130 °C

실험 절차

The mixture of 1.86 g of 3-(pentafluoroethyl)-1H-pyrazole and 0.60 g of paraformaldehyde was stirred at 130° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added. The mixture was filtered. The filtrate was concentrated under reduced pressure to obtain 1.98 g of 3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol.

후처리

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-43c92962c4fa4633a2ee2347d7f766f7
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541374B2

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