Formaldehyde → 4-bromo-3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol

HRID 1983045노트

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HRID 1983045 반응식
[Br:1][C:2]1[C:3]([C:7]([F:13])([F:12])[C:8]([F:11])([F:10])[F:9])=[N:4][NH:5][CH:6]=1.[CH2:14]=[O:15]>CC(C)=O>[Br:1][C:2]1[C:3]([C:7]([F:13])([F:12])[C:8]([F:9])([F:10])[F:11])=[N:4][N:5]([CH2:14][OH:15])[CH:6]=1

참가 물질

4

반응물 2

HCID 712FormaldehydeHCID 178506331HCID 178506331, 화합물

생성물 1

HCID 231491334-bromo-3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol수율 50.3%

시약·촉매·용매 1

HCID 180Acetone용매

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온도
130 °C

실험 절차

The mixture of 13.72 g of 4-bromo-3-(pentafluoroethyl)-1H-pyrazole and 3.00 g of paraformaldehyde was stirred at 130° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added. The mixture was filtered. The filtrate was concentrated under reduced pressure. Hexane was added to the filtrate, as a result, a crystal was formed. The crystal was collected to obtain 7.69 g of 4-bromo-3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol.

후처리

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationThe mixture was filtered
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. additionHexane was added to the filtrate, as a result
  5. customa crystal was formed
  6. customThe crystal was collected

출처 및 근거

ORD 기록
ord-c67c9c6a8c9245d48876786e720d34a7
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541374B2

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