Thionyl Chloride → 4-bromo-1-(chloromethyl)-3-(pentafluoroethyl)-1H-pyrazole

HRID 1983046노트

반응식

HRID 1983046 반응식
[Br:1][C:2]1[C:3]([C:9]([F:15])([F:14])[C:10]([F:13])([F:12])[F:11])=[N:4][N:5]([CH2:7]O)[CH:6]=1.S(Cl)([Cl:18])=O>ClCCl>[Br:1][C:2]1[C:3]([C:9]([F:15])([F:14])[C:10]([F:13])([F:12])[F:11])=[N:4][N:5]([CH2:7][Cl:18])[CH:6]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 231491334-bromo-3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol

생성물 1

HCID 231491944-bromo-1-(chloromethyl)-3-(pentafluoroethyl)-1H-pyrazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

6.49 g of 4-bromo-3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol was dissolved to 60 ml of dichloromethane. 3.2 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 6.84 g of 4-bromo-1-(chloromethyl)-3-(pentafluoroethyl)-1H-pyrazole.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-96d77e08646f48fbbae403a54c833d69
출처 데이터셋
uspto-grants-2009_06
특허 번호
US07541374B2

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